I have an iMac and use Chrome exclusively. As you have noted certain things may not work or work differently in Safari. There have been occasions when I could not use Chrome and in those instances switched to Safari to get by.
In case you are not aware, and for anyone else reading, all web based applications and websites need to be coded specifically for each web browser. While there is a LOT of standard overlap amongst them all, each browser has its own way of handling the non-standard things as well as each trying to assert their own awesome features. This is why we have several different browsers (anyone remember Netscape?)
Most tech companies will publish which browsers and version they currently support. I don't know if AppSheet does. I did find this article but it doesn't provide details : Supported mobile devices and browsers
Appsheet abstracts all of the browser specific implementations into their platform so we don't need to worry about it. But they are going to focus on where the market share is. Safari doesn't have great market share so its compatibility may be sketchy in some areas.
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